@article{(CRISUNS)49389,
	title = {Green pathway for utilisation of orange peel dust and in silico evaluation of pharmacological potential},
	abstract = {This study is focused on the investigation of the new ways of valorization and maximal utilisation of the fruit dust obtained from the orange peel during industrial processing in the filter tea production. Therefore, the possibility of the integration of two attractive “green” extraction methods, CO<inf>2</inf>-assisted extraction and ultrasound-assisted extraction (UAE), were investigated. In the first step to produce herbal extracts, supercritical carbon dioxide (Sc-CO<inf>2</inf>) extraction of the orange peel dust (OPD) was applied in the pressure range of 10–30 MPa. The second step was UAE of the OPD remaining after the Sc-CO<inf>2</inf> extraction, with varying sonication amplitudes (20–100%). Gas chromatography combined with mass spectrometry was used for the chemical characterization of Sc-CO<inf>2</inf> extracts. Among the valuable volatile compounds, the most abundant are linoleic (31.11–41.47%) and hexadecanoic (15.22–20.58%) acid, osthol (4.53–5.42%), and 7-methoxy-8-(2-oxo-3-methylbutyl) coumarin (12.65–15.45%). Extracts obtained by UAE were analyzed by HPLC, where the dominant compounds were identified as hesperidin (848–900.24 [µg/ml]), narirutin (16.70–18.16 [µg/ml]), naringin (771.45––830.39 [µg/ml]) and rutin (47.53–104.40 [µg/ml]). Finally, the in silico testing was performed to identify pharmacologically the most valuable bioactive compounds in the extracts, and to enable screening of the possible pharmacological effect and applications of the obtained.},
	keywords = {Herbaldust
		Insilicoevaluation
		Orangepeel
		Polyphenols
		Supercriticalextraction
		Ultrasound-assistedextraction},
	author = {Slađana Krivošija and Igor Jerković and Nataša Nastić and Mire Zloh and Stela Jokić and Marija Banožić and Krunoslav Aladić and Senka Vidović},
	year = {2023},
	doi = {10.1016/j.microc.2023.109132},
	scopusId = {85166216235},
	url = {https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85166216235&origin=inward},
	journal = {Microchemical Journal},
	e_issn = {0026-265X}
}